13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E₁-d₄

Biochemicals - Isotopically Labeled Standards

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Cat No: 9000406

Biochemicals - Isotopically Labeled Standards

PGE1 is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM) and increases vasodilation.{960,4165}13,14-dihydro-16,16-difluoro PGE1 is a biologically active meta...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9-oxo-11?,15R,S-dihydroxy-16,16-difluoro-prostan-1-oic-3,3,4,4-d4 acid

Correlated keywords:

lubiprostone chloride channel epithelial cell constipation gastrointestinal amitiza RU-0211 RU0211 SPI-0211 SPI0211 PGE1 PGE2 Prostaglandin E2 gastroprotection 15-hydroxy Lubiprostone 475992-30-4

Product Overview:
PGE1 is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM) and increases vasodilation.{960,4165}13,14-dihydro-16,16-difluoro PGE1 is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound.{2126,4165} The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation in vivo.{17623} 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro PGE1-3,3’,4,4’-d4) contains four deuterium atoms at the 3, 3’, 4, and 4’ positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1 by GC- or LC-mass spectrometry (MS).

Size	25 µg
Shipping	dry ice
Molecular Formula	C₂₀H₃₀D₄F₂O₅
SMILES	O=C1[C@H](CCCC([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](CCC(O)C(F)(F)CCCC)[C@H](O)C1
Molecular Weight	396,5
Formulation	A solution in methyl acetate
Purity	≥99% deuterated forms (d1-d4)
Custom Code	3822.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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