13,14-dihydro-16,16-difluoro Prostaglandin E₁

Biochemicals - Lipids

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Cat No: 9000405

Biochemicals - Lipids

Prostaglandin E1 (PGE1) is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM){960,4165} and increases vasodilation. 13,14-dihydro-16,16-difluoro PGE1 is an anal...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9-oxo-11?,15S-dihydroxy-16,16-difluoro-prostan-1-oic acid

Correlated keywords:

prostaglandins E1 PGE1 chloride channels Amitiza constipation irritable bowel syndrome platelets dilation vasodilation hypotension metabolite of lubiprostone

Product Overview:
Prostaglandin E1 (PGE1) is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM){960,4165} and increases vasodilation. 13,14-dihydro-16,16-difluoro PGE1 is an analog of PGE1. 13,14-dihydro PGE1 is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound.{2126,4165} The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation in vivo.{17623}

Size	100 µg
Shipping	dry ice
CAS Number	475992-30-4
Molecular Formula	C₂₀H₃₄F₂O₅
SMILES	O=C1[C@H](CCCCCCC(O)=O)[C@@H](CC[C@@H](O)C(F)(F)CCCC)[C@H](O)C1
Molecular Weight	392,5
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2937.50
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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