Amyloid-? (1-8, A2V) Peptide
Amyloid-? (1-8, A2V) Peptide
Amyloid-? (1-8, A2V) is a truncated form of amyloid-? (A?) that contains a valine to alanine substitution at position 2...
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€598.00 €508.30
€598.00 €508.30
Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide (Item No. 24183) by GC- or LC-MS. Zonisamide is an antiepileptic agent.{41543} It selectively inhibits the repeated firing of sodium channels (IC50 = 2 ?g/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 ?g/ml.{41545} In rat cerebral cortex neurons, zonisamide (1-1,000 ?M) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium current.{41546} Zonisamide inhibits H. pylori recombinant carbonic anhydrase (CA) and the human CA isoforms I, II, and V with Ki values of 218, 56, 35, and 21 nM, respectively.{33180,41544} In mice, it has anticonvulsant activity against maximal electroshock seizure (MES) and pentylenetetrazole-induced maximal, but not minimal, seizures (ED50s = 19.6, 9.3, and >500 mg/kg, respectively). Zonisamide (40 mg/kg, p.o.) prevents MPTP-induced decreases in the levels of dopamine (Item No. 21992), but not homovanillic acid (HVA; Item No. 27307) or dihydroxyphenyl acetic acid (DOPAC; Item No. 24912), and increases MPTP-induced decreases in the dopamine turnover rate in mouse striatum in a model of Parkinson’s disease.{45492} Formulations containing zonisamide have been used in the treatment of partial seizures in adults with epilepsy.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 1188265-58-8 |
| Molecular formula | C6[13C]2H8N[15N]O3S |
| Smiles | [15NH2]S([13CH2][13C]1=NOC2=CC=CC=C21)(=O)=O |
| Molecular weight | 215,2 |
| Formulation | A solid |
| Purity | ≥95% |
| Custom code | 3822.19 |
| UNSPSC code | 12352100 |
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