YK-3-237

YK-3-237

CAT N°: 21516
Price:

From 48.00 40.80

YK-3-237 is a chalcone derivative and an activator of sirtuin 1 (SIRT1).{36848,36849} It inhibits colchicine binding to tubulin in a concentration-dependent manner and tubulin polymerization (IC50 = 31 ?M) and induces microtubule loss in A-10 cells (EC50 = 16.5 ?M).{36848} YK-3-237 inhibits cell growth in a panel of leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast cancer cell lines (GI50s = 50s = 0.160-5.031 ?M).

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