XY1

XY1

CAT N°: 17518
Price:

159.00 135.15

159.00 135.15

Protein arginine N-methyltransferase 3 (PRMT3, Item No. 11642) is a predominantly cytoplasmic enzyme that is constitutively expressed.{21260,20245} SGC707 (Item No. 17017) is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). It inhibits the methylation of histones in cells with an IC50 value below 1 µM. XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 µM.{28447} It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action. See the Structural Genomics Consortium (SGC) website for more information.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-2-naphthalenyl-N’-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea
  • Correlated keywords
    • biochemical inhibitor methyltransferase epigenetic histone modification intracellular signaling inhibit negative control SGC707 SGC 707 XY 1 structural genomics consortium
  • Product Overview:
    Protein arginine N-methyltransferase 3 (PRMT3, Item No. 11642) is a predominantly cytoplasmic enzyme that is constitutively expressed.{21260,20245} SGC707 (Item No. 17017) is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). It inhibits the methylation of histones in cells with an IC50 value below 1 µM. XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 µM.{28447} It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action. See the Structural Genomics Consortium (SGC) website for more information.

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