Wiskostatin

Wiskostatin

CAT N°: 15047
Price:

174.00 147.90

Wiskott-Aldrich syndrome proteins (WASPs) regulate the actin cytoskeleton by directly interacting with actin in the Arp2/3 complex.{23890} As a result, they have essential functions in diverse cellular processes, including phagocytosis, cell motility, and membrane trafficking.{23889} Wiskostatin is a cell-permeable, selective inhibitor of neural WASP (N-WASP, IC50 = ~10 ?M).{23889} It directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and phosphatidylinositol 4,5-bisphosphate.{23889} By inhibiting N-WASP, wiskostatin interferes with membrane transport, endocytosis, and neurological development.{23891,23887,23888}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3,6-dibromo-?-[(dimethylamino)methyl]-9H-carbazole-9-ethanol
  • Correlated keywords
    • cytoskeletal researchs neurosciences cells biology WASPs wiskott-aldrich wiskott Aldrich syndromes proteins cell-permeable cells permeable inhibitors inhibits inhibitions neural n-WASPs GTPase-binding GTPase-binding binds binder Cdc42 Cdc-42 Cdc 42 PIP2 phosphatidylinositol 4,5-bisphosphate transports endocytosis neurological developments regulates actins cytoskeletons Arp2/3 complex Arp 2/3 cellular processes phagocytosis motility membranes trafficking wiskostatin selectives activations domains
  • Product Overview:
    Wiskott-Aldrich syndrome proteins (WASPs) regulate the actin cytoskeleton by directly interacting with actin in the Arp2/3 complex.{23890} As a result, they have essential functions in diverse cellular processes, including phagocytosis, cell motility, and membrane trafficking.{23889} Wiskostatin is a cell-permeable, selective inhibitor of neural WASP (N-WASP, IC50 = ~10 ?M).{23889} It directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and phosphatidylinositol 4,5-bisphosphate.{23889} By inhibiting N-WASP, wiskostatin interferes with membrane transport, endocytosis, and neurological development.{23891,23887,23888}

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