WIN 18,446

WIN 18,446

CAT N°: 14018
Price:

From 92.00 78.20

WIN 18,446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2, (IC50 = 300 nM), a testes-specific isoform of the enzyme involved in vitamin A metabolism.{23122} In this way, WIN 18,446 suppresses the expression of several genes that are regulated by retinoic acid and are necessary for spermatogenesis.{23123,23122} As a result, WIN 18,446 may cause infertility in males.{23123,23122}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N,N’-1,8-octanediylbis[2,2-dichloro-acetamide]
  • Correlated keywords
    • 1071707-69-1 Inhibitors reproductives biology inhibits inhibitions aldehydes dehydrogenases 1a2 ALDH1a2 ALDH-1a2 ALDG bis-(dichloroacetyl)-diamine testes-specific testes isoforms enzymes vitamins A metabolisms genes expressions retinoic acids spermatogenesis infertility males men WIN-18,446 WIN18,446 WINs 18,446 18446 18-446 WIN-18446 WIN-18-446 WIN18446 WIN18-446 bis-diamine bis diamines bisdiamines fertilysins fertilysines NSCs 59354 NSC-59354 NSC59354 suppresses
  • Product Overview:
    WIN 18,446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2, (IC50 = 300 nM), a testes-specific isoform of the enzyme involved in vitamin A metabolism.{23122} In this way, WIN 18,446 suppresses the expression of several genes that are regulated by retinoic acid and are necessary for spermatogenesis.{23123,23122} As a result, WIN 18,446 may cause infertility in males.{23123,23122}

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