24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38? and p38? (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion.{21533} It inhibits IL-6, IL-1?, and TNF-? production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively.{21533} VX-702, at 1 ?M, inhibits activation of p38 in platelets by thrombin, U-46619 (Item No. 16450), or collagen but does not block platelet aggregation in response to collagen.{21534} Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.{21532}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 745833-23-2 |
| Molecular formula | C19H12F4N4O2 |
| Smiles | FC1=CC=CC(F)=C1N(C2=NC(C3=C(F)C=C(F)C=C3)=C(C(N)=O)C=C2)C(N)=O |
| Molecular weight | 404,3 |
| Custom code | 2903.99 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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