Voacamine

Voacamine

CAT N°: 25204
Price:

From 122.00 103.70

Voacamine is an alkaloid originally isolated from Voacanga that has diverse biological activities.{37654} It is a cannabinoid receptor 1 (CB1) antagonist (IC50 = 41 nM).{37655} Voacamine (1-10 µg/ml) time- and dose-dependently decreases survival of U2OS and multi-drug resistant U2OS (U2OS/DX) osteosarcoma cells and induces autophagy but not apoptosis.{37656} It also has antimalarial activity, inhibiting growth of P. falciparum in vitro at the trophozoite and schizont stages and reducing parasitemia in mice infected with P. yoelii when administered at doses of 2.5, 5, and 10 mg/kg.{37657}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 12-methoxy-13-[(3?)-17-methoxy-17-oxovobasan-3-yl]-ibogamine-18-carboxylic acid, methyl ester
  • Correlated keywords
    • CB-1 multidrug U2O-S anti-malarial plasmodium MMH 18 MMH18 Malarex NSC82591 Voacanginine
  • Product Overview:
    Voacamine is an alkaloid originally isolated from Voacanga that has diverse biological activities.{37654} It is a cannabinoid receptor 1 (CB1) antagonist (IC50 = 41 nM).{37655} Voacamine (1-10 µg/ml) time- and dose-dependently decreases survival of U2OS and multi-drug resistant U2OS (U2OS/DX) osteosarcoma cells and induces autophagy but not apoptosis.{37656} It also has antimalarial activity, inhibiting growth of P. falciparum in vitro at the trophozoite and schizont stages and reducing parasitemia in mice infected with P. yoelii when administered at doses of 2.5, 5, and 10 mg/kg.{37657}

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