(–)-Viriditoxin

(–)-Viriditoxin

CAT N°: 26601
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(?)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity.{47137,47138,47139,47140} It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 ?g/ml).{47138} (?)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MICs = 0.16-0.21 ?g/ml).{47139} It inhibits polymerization and the GTPase activity of E. coli FtsZ, a tubulin-like GTPase involved in bacterial cell division (IC50s = 8.2 and 7 ?g/ml, respectively).{47138} (?)-Viriditoxin inhibits proliferation of human DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5.36, 0.63, and 7.6 ?M, respectively) .{47140} It is also toxic to mice (LD50 = 2.8 mg/kg, i.p.).{47141}

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Please check regulation status before ordering; additionel fees can apply.

  • Synonyms
    • (3S,3’S,6R)-3,3′,4,4′-tetrahydro-9,9′,10,10′-tetrahydroxy-7,7′-dimethoxy-1,1′-dioxo-[6,6′-bi-1H-naphtho[2,3-c]pyran]-3,3′-diacetic acid, 3,3′-dimethyl ester
  • Correlated keywords
    • SC 28762 SC28762 Aspergillus bacterial anti-proliferative Streptococcus GTP Escherichia DU 145 PC 3 VDT
  • Product Overview:
    (?)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity.{47137,47138,47139,47140} It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 ?g/ml).{47138} (?)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MICs = 0.16-0.21 ?g/ml).{47139} It inhibits polymerization and the GTPase activity of E. coli FtsZ, a tubulin-like GTPase involved in bacterial cell division (IC50s = 8.2 and 7 ?g/ml, respectively).{47138} (?)-Viriditoxin inhibits proliferation of human DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5.36, 0.63, and 7.6 ?M, respectively) .{47140} It is also toxic to mice (LD50 = 2.8 mg/kg, i.p.).{47141}

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