Vinyl-<wbr/>L-<wbr/>NIO (hydro<wbr>chloride)

Vinyl-L-NIO (hydrochloride)

CAT N°: 80330
Price:

From 82.00 69.70

Vinyl-L-NIO is a potent, selective inhibitor of nNOS. The Ki values for inhibition of nNOS, eNOS, and iNOS by vinyl-L-NIO are 100 nM, 12 and 60 µM, respectively, as determined using initial rate measurements.{6358} In the presence of NADPH and O2, vinyl-L-NIO irreversibly inactivates nNOS with a kinact of 0.078 min?1 and a Ki value of 90 nM. Vinyl-L-NIO does not inactivate iNOS. eNOS requires 20-fold higher concentrations of vinyl-L-NIO to obtain 75% the rate of inactivation seen with nNOS.{6358}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N5-(1-imino-3-butenyl)-L-ornithine, monohydrochloride
  • Correlated keywords
    • nitric oxide synthase NOS nNOS selective inhibitors inhibits inhibition ornithine
  • Product Overview:
    Vinyl-L-NIO is a potent, selective inhibitor of nNOS. The Ki values for inhibition of nNOS, eNOS, and iNOS by vinyl-L-NIO are 100 nM, 12 and 60 µM, respectively, as determined using initial rate measurements.{6358} In the presence of NADPH and O2, vinyl-L-NIO irreversibly inactivates nNOS with a kinact of 0.078 min?1 and a Ki value of 90 nM. Vinyl-L-NIO does not inactivate iNOS. eNOS requires 20-fold higher concentrations of vinyl-L-NIO to obtain 75% the rate of inactivation seen with nNOS.{6358}

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