Urolithin A

Urolithin A

CAT N°: 22607
Price:

51.00 43.35

Urolithin A is a secondary metabolite of ellagic acid (Item No. 10569), a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.{40131} It decreases proliferation in ECC-1, Ishikawa, and HEC-1A human endometrial cancer cell lines at a concentration of 1 µM, arrests the cell cycle at the G2/M transition, and modulates estrogen receptor-regulated gene expression.{40132} It also potentiates the antiproliferative effect of 5-fluorouracil (Item No. 14416) in Caco-2, SW480, and HT-29 cells.{40128} In a rat model of colitis, urolithin A reduces inflammation, decreasing prostaglandin E2 (PGE2; Item No. 14010) levels and preventing upregulation of COX-2 gene expression and protein levels in colonic mucosa.{40129} It also induces mitophagy in C. elegans, C2C12 myoblasts, and Mode-K intestinal cells in correlation with improved fitness and extended lifespan in C. elegans and increased exercise capacity in mice.{40130}

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