Urocortin (rat) (trifluoroacetate salt)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • L-?-aspartyl-L-?-aspartyl-L-prolyl-L-prolyl-L-leucyl-L-seryl-L-isoleucyl-L-?-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-threonyl-L-leucyl-L-leucyl-L-?-glutamyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-glutaminyl-L-seryl-L-glutaminyl-L-arginyl-L-?-glutamyl-L-arginyl-L-alanyl-L-?-glutamyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-phenylalanyl-L-?-aspartyl-L-seryl-L-valinamide, trifluoroacetate salt
• Correlated keywords
  • CRFBP CRF-1 2?
• Product Overview:
  Urocortin is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF (Item No. 24407), urocortin II (Item Nos. 24746 | 24747), urocortin III (Item Nos. 24748 | 24749 | 24750), frog sauvagine, and piscine urotensin I.{38851} Rat urocortin shares 63 and 45% sequence identity to urotensin and CRF, respectively. It is primarilly expressed in the Edinger-Westphal nucleus and lateral superior olive regions in the adult rat brain but can also be expressed in the periphery. Urocortin binds to type 1 and 2 CRF receptors as well as CRF binding protein (CRF-BP) with Ki values of 0.16, 0.41, and 0.10 nM for CRF1, CRF2?, and CRF-BP, respectively. It induces cAMP production in CHO cells expressing CRF1 and CRF2? (EC50s = 0.8 and 0.18 nM, respectively) and secretion of adrenocorticotropic hormone (ACTH) by rat anterior pituitary cells (EC50 = 0.006 nM). In vivo, urocortin (0.94-18.85 ?g/kg) decreases mean arterial pressure and increases plasma levels of ACTH in rats. Urocortin inhibits gastric emptying of a solid meal in mice and rats and inhibits gastric motility and transit induced by vagal stimulation in rats.{38852} Levels of urocortin mRNA increase in testis in response to ischemia-reperfusion injury in a rat model of testicular torsion.{38853}