Tubastatin A (trifluoro<wbr/>acetate salt)

Tubastatin A (trifluoroacetate salt)

CAT N°: 10559
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Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.{18338} Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 ?M), excluding HDAC8 (IC50 = 0.9 ?M).{18338} Tubastatin A induces ?-tubulin hyperacetylation at 2.5 ?M in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 ?M.{18338}

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