Triptolide

Triptolide

CAT N°: 11973
Price:

From 48.00 40.80

Triptolide is a diterpenoid triepoxide that has been found in T. wilfordii and has diverse biological activities.{22058,57803,57804,57805} It inhibits dCTP pyrophosphatase 1 (Ki = 168 µM), an enzyme that prevents halogenated nucleotides from entering DNA synthesis.{22058} It reduces viability of A549, H1299, NCI H520, NCI H1650, and H1975 human non-small cell lung cancer (NSCLC) cells when used at a concentration of 50 nM.{57803} Intranasal administration of liposomes containing triptolide (0.4 mg/kg) reduces tumor growth in a rat orthotopic model of lung cancer. Triptolide (0.2 mg/kg) reduces intestinal inflammation and prevents colon shortening in a mouse model of colitis induced by dextran sulfate (Item No. 23250).{57804} It also inhibits skin allograft rejection and increases graft survival time in mice when administered at a dose of 0.1 mg/kg per day post-transplantation.{57805}

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