trans–Resveratrol-d₄

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol-2,3,5,6-d4
• Correlated keywords
  • selective cyclooxygenases inhibitors COX1 PGHS-1 COX1 PGHS1 prostaglandins H synthases 1 anti-oxidants antiinflammatory cancer oxidative injury stress atherosclerosis deuterated LC/MS GCMS LCMS mass spectrometry deuterium sirtuins AHR antagonists aryl hydrocarbon receptors Caenorhabditis Drosophila JNK-1 ERK-1 deuterated deuterium
• Product Overview:
  trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol (Item No. 70675) by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 ?M, respectively), but not COX-2 (EC50s = >100 ?M and 85 ?M, respectively).{3491} trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014; EC50 = 27 ?M). trans-Resveratrol (1-25 ?mol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 ?M) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKC?, aromatase/CYP19, and DNA polymerases ? and ? (IC50s = 37, 50, 20, in vitro and/or ex vivo.{13296,43362} It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}