<em>trans</em>-<wbr/>Resveratrol

trans–Resveratrol

CAT N°: 70675
Price:

From 37.00 31.45

trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 ?M, respectively) but not COX-2 (EC50s = >100 ?M and 85 ?M, respectively).{3491} trans-Resveratrol (200 ?M) also activates sirtuin 1 (SIRT1), as well as inhibits a variety of targets including ERK1, JNK1, Src, PKC?, aromatase/CYP19, and DNA polymerases ? and ? (IC50s = 37, 50, 20, in vitro.{13296,43362} It inhibits free radical formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells and reduces the tumor incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. Intravaginal administration of trans-resveratrol (12.5% v/v) inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication and delays the development of extravaginal disease in mouse models of vaginal HSV infection.{60119} It also prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol
  • Correlated keywords
    • Trihydroxystilbene Trihydroxy-stilbene Stilbenetriol Trihydroxy-trans-stilbene Biofort CA-1201 CA1201 Cuspidatin Melinjo Resveratrol 20 Polygonin Regu-Fade P-5 P5 Resvida SRT-501 501M 501-M SRT501 SRT501M Vineatrol 20M 20-M Cyclo-oxygenase hydro-peroxidase COX1 COX2 SIRT-1 ERK1 JNK-1 PKC-? CYP-19 HL60 HSV1 HSV2 Caenorhabditis Drosophila antiinflammatory anti-viral
  • Product Overview:
    trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 ?M, respectively) but not COX-2 (EC50s = >100 ?M and 85 ?M, respectively).{3491} trans-Resveratrol (200 ?M) also activates sirtuin 1 (SIRT1), as well as inhibits a variety of targets including ERK1, JNK1, Src, PKC?, aromatase/CYP19, and DNA polymerases ? and ? (IC50s = 37, 50, 20, in vitro.{13296,43362} It inhibits free radical formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells and reduces the tumor incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. Intravaginal administration of trans-resveratrol (12.5% v/v) inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication and delays the development of extravaginal disease in mouse models of vaginal HSV infection.{60119} It also prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}

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