<em>trans</em>-<wbr/>3'-<wbr/>Hydroxy<wbr/>cotinine

trans–3′-Hydroxycotinine

CAT N°: 16100
Price:

From 85.00 72.25

trans-3’-Hydroxycotinine (3HC) is a product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine (Item No. 15314).{26187,26185} Cotinine has a longer metabolic half-life compared to 3HC (16 hours vs. 5 hours).{26187} The ratio of 3HC to cotinine, termed the nicotine metabolite ratio, correlates with nicotine clearance from the body and is used as a biomarker of CYP2A6 activity.{26187} This measure of nicotine metabolism has been used to study tobacco and secondhand smoke exposure as well as to develop pharmacological intervention strategies for smoking cessation.{26187,26186}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3R-hydroxy-1-methyl-5S-(3-pyridinyl)-2-pyrrolidinone
  • Correlated keywords
    • 27323-?64-?4 108450-?02-?8 nicotine tobacco metabolites biomarkers CYP2A6 metabolism cotinine ratio alkaloids toxicology hydroxy trans 3 three CYP2A6 biomarkers smoke smoking smokers exposures cessation secondhand
  • Product Overview:
    trans-3’-Hydroxycotinine (3HC) is a product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine (Item No. 15314).{26187,26185} Cotinine has a longer metabolic half-life compared to 3HC (16 hours vs. 5 hours).{26187} The ratio of 3HC to cotinine, termed the nicotine metabolite ratio, correlates with nicotine clearance from the body and is used as a biomarker of CYP2A6 activity.{26187} This measure of nicotine metabolism has been used to study tobacco and secondhand smoke exposure as well as to develop pharmacological intervention strategies for smoking cessation.{26187,26186}

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