Trandolaprilat (hydrate)

Trandolaprilat (hydrate)

CAT N°: 29577
Price:

72.00 61.20

Trandolaprilat is an angiotensin-converting enzyme (ACE) inhibitor.{52253} It inhibits angiotensin I-induced contraction in isolated rat thoracic aorta (IC50 = 6.9 nM) and potentiates bradykinin-induced contraction in isolated guinea pig ileum with a 50% augmentation concentration (AC50) value of 2.7 nM. Trandolaprilat induces relaxation of norepinephrine- or potassium chloride-precontracted isolated rat thoracic aorta with intact endothelium in a concentration-dependent manner. Trandolaprilat inhibits angiotensin I-induced pressor responses in rats and dogs (ID50s = 9.9 and 7.2 ?g/kg, respectively) and potentiates the bradykinin-induced depressor response in rats (ED50 = 4.1 ?g/kg).{52254}

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