Toyocamycin (hydrate)

Toyocamycin (hydrate)

CAT N°: 17371
Price:

From 48.00 40.80

Toyocamycin is a natural adenosine analog first isolated from Streptomyces and shown in early studies to be cytotoxic to bacteria, fungi, and cancer cells and to have antiviral activities. Toyocamycin prevents IRE1?-induced mRNA cleavage (IC50 = 80 nM) and inhibits constitutive activation of XBP1 in multiple myeloma cell lines.{31592} It is used to study IRE1? action in the endoplasmic reticulum stress response, particularly in the context of cancer.{31589,31593} It also inhibits phosphatidylinositol kinase in vitro (IC50 = 3.3 µg/ml), but not in cells, and blocks the ribosomal RNA-processing kinase Rio1 (IC50 = ~30 nM).{31591,31590}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-amino-7-?-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, hydrate
  • Correlated keywords
    • anti-biotic 1037 E 212 E212 MT 1155 MT1155 NSC63701 NSC99843 SIPI 763-1 SIPI763-1 SIPI7631 SIPI-763-1 SIPI-7631 toyokamycin unamycin B vengicide IRE1? IRE1-? IRE-1? IRE-1-? IRE1a IRE1-a IRE-1a IRE-1-a adenosine anti-viral XBP-1 Rio-1 ER 58151-27-2 606-58-6
  • Product Overview:
    Toyocamycin is a natural adenosine analog first isolated from Streptomyces and shown in early studies to be cytotoxic to bacteria, fungi, and cancer cells and to have antiviral activities. Toyocamycin prevents IRE1?-induced mRNA cleavage (IC50 = 80 nM) and inhibits constitutive activation of XBP1 in multiple myeloma cell lines.{31592} It is used to study IRE1? action in the endoplasmic reticulum stress response, particularly in the context of cancer.{31589,31593} It also inhibits phosphatidylinositol kinase in vitro (IC50 = 3.3 µg/ml), but not in cells, and blocks the ribosomal RNA-processing kinase Rio1 (IC50 = ~30 nM).{31591,31590}

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