Tocofersolan

Tocofersolan

CAT N°: 34661
Price:

48.00 40.80

Tocofersolan is a nonionic surfactant and derivative of vitamin E.{62421} It has a critical micelle concentration (CMC) of 0.02 mM at room temperature. Tocofersolan inhibits P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), substrate-induced ATPase activity in cell-free assays (IC50s = 0.4-3.25 µM).{62422} It reverses locomotor deficits induced by the polycyclic aromatic hydrocarbon benzo[a]pyrene in zebrafish larvae when used at a concentration of 1 µM.{62423} Intravenous administration of nanocrystals containing tocofersolan (50 mg/kg) and paclitaxel (Item No. 10461) reduces tumor growth in an NCI/ADR-RES mouse xenograft model.{62424}

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