TNP-470

TNP-470

CAT N°: 16449
Price:

94.00 79.90

TNP-470 is a synthetic analog of fumagillin (Item No. 11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo.{26940,26939,13713} It is without effect on MetAP1.{26940} TNP-470 has therapeutic potential in cancer and microsporidiosis.{13713,26938}

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