Tiotropium-d<sub>3</sub> (bromide)

Tiotropium-d3 (bromide)

CAT N°: 25285
Price:

From 231.00 196.35

Tiotropium-d3 is intended for use as an internal standard for the quantification of tiotropium (Item No. 15773) by GC- or LC-MS. Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors).{42255} It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled aerosol) confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs. Formulations containing tiotropium have been used in the treatment of chronic obstructive pulmonary disease (COPD).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1?,2?,4?,5?,7?)-7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9-methyl-9-(methyl-d3)-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide
  • Correlated keywords
    • 1127116-70-4 1126775-93-6 deuterated deuterium M-1 2 3 BA 679BR BA679BR
  • Product Overview:
    Tiotropium-d3 is intended for use as an internal standard for the quantification of tiotropium (Item No. 15773) by GC- or LC-MS. Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors).{42255} It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled aerosol) confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs. Formulations containing tiotropium have been used in the treatment of chronic obstructive pulmonary disease (COPD).

We also advise you