From €202.00 €171.70
Thioredoxin 2 (Trx2) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular redox homeostasis.{55539} It is ubiquitously expressed, with the highest levels of expression in metabolically active tissues such as the heart, skeletal muscle, testis, kidney, adrenal gland, and brain, and is localized to the mitochondria.{69093,69094} Trx2 contains two active site cysteine residues, but lacks the additional structural cysteines present in Trx1 that participate in dimerization.{69095} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{55539} Trx2 is upregulated by TNF-? and reactive oxygen species (ROS), inhibits TNF-?-induced NF-?B activation, and inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{69096,69097} Homozygous disruption of the gene encoding Trx2, Txn2, causes exencephaly and is embryonic lethal in mice.{69098} Trx2 deficiency is associated with premature neurodegeneration.{69099} Cayman’s Thioredoxin 2 Rabbit Monoclonal Antibody (Clone 054) can be used for immunohistochemistry (IHC).
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl, 50 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | |
| Antigen | Recombinant human Trx2 |
| Host | Rabbit |
| Clone | 54 |
| Isotype | IgG |
| Custom code | 3822.19 |
| Application(s) | IHC |
| Formulation | 50 or 100 µl of protein A-affinity purified monoclonal antibody |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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