24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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€249.00 €211.65
Thiocoraline is a depsipeptide and DNA bis-intercalator originally isolated from Micromonospora with antibacterial and anticancer activities.{53564,53565} It is active against the Gram-positive bacteria S. aureus, B. subtilis, and M. luteus (MICs = 0.05, 0.05, and 0.03 µg/ml, respectively) but not Gram-negative E. coli, K. pneumoniae, or P. aeruginosa (MICs = >100 µg/ml for all).{53564} Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 µg/ml, respectively), as well as RNA and DNA synthesis in vitro (IC50s = 0.008 and 0.4 µg/ml, respectively). It is cytotoxic to P388, A549, HT-29, and MEL-28 cancer cells (IC50s = 0.002, 0.002, 0.01, and 0.002 µg/ml, respectively).
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 173046-02-1 |
| Molecular formula | C48H56N10O12S6 |
| Smiles | O=C([C@H](CSC)N(C([C@H]1N(C)C(CNC([C@H](NC(C2=NC(C=CC=C3)=C3C=C2O)=O)CSC([C@H](CSC)N(C)C([C@H](CSSC1)N4C)=O)=O)=O)=O)=O)C)SC[C@@H](NC(C5=NC(C=CC=C6)=C6C=C5O)=O)C(NCC4=O)=O |
| Molecular weight | 1157,4 |
| Formulation | A solid |
| Purity | ≥70% |
| Custom code | 3504.00 |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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