Tetrabenazine<wbr/>-d<sub>6</sub>

Tetrabenazine-d6

CAT N°: 26811
Price:

85.00 72.25

Tetrabenazine-d6 is intended for use as an internal standard for the quantification of tetrabenazine (Item No. 20380) by GC- or LC-MS. Tetrabenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2) that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay).{26973} It dose-dependently reduces levels of the monoamines norepinephrine (Item No. 16673), dopamine (Item No. 21992), and serotonin (5-HT; Item No. 14332) in rat brain and has been used to induce depressive-like behavior in animal models.{47227,47228} Tetrabenazine (5 mg/kg) improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal medium spiny neurons (MSNs) in a YAC128 transgenic mouse model of Huntington’s disease.{47229} Formulations containing tetrabenazine have been used in the treatment of chorea associated with Huntington’s disease.

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