Telaprevir-d<sub>4</sub>

Telaprevir-d4

CAT N°: 31317
Price:

1,055.00 896.75

Telaprevir-d4 is intended for use as an internal standard for the quantification of telaprevir (Item No. 20054) by GC- or LC-MS. Telaprevir is an inhibitor of hepatitis C virus (HCV) nonstructural protease 3/4A (NS3/4A; Ki = 7 nM).{51075} It inhibits viral replication in genotype 1b HCV replicon cells and isolated human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50s = 354 and 280 nM, respectively). Telaprevir (10-300 mg/kg) reduces plasma levels of a secreted placental alkaline phosphatase (SEAP) reporter gene in a mouse model of HCV NS3/4A protease activity. Formulations containing telaprevir have been used in the treatment of HCV.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-((cyclopropyl-2,2,3,3-d4)amino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
  • Correlated keywords
    • LY570310 LY 570310 VX-950 VX950 deuterated deuterium NS 3/4A 1 b a Incivek Incivo MP-424 MP424 VRT111950 Telavic VRT 111950 non structural
  • Product Overview:
    Telaprevir-d4 is intended for use as an internal standard for the quantification of telaprevir (Item No. 20054) by GC- or LC-MS. Telaprevir is an inhibitor of hepatitis C virus (HCV) nonstructural protease 3/4A (NS3/4A; Ki = 7 nM).{51075} It inhibits viral replication in genotype 1b HCV replicon cells and isolated human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50s = 354 and 280 nM, respectively). Telaprevir (10-300 mg/kg) reduces plasma levels of a secreted placental alkaline phosphatase (SEAP) reporter gene in a mouse model of HCV NS3/4A protease activity. Formulations containing telaprevir have been used in the treatment of HCV.

We also advise you