TC-E 5003

TC-E 5003

CAT N°: 17718
Price:

From 66.00 56.10

TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 µM for human PRMT1 in a methylation assay).{38415} It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 µM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 µM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.{38416}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N,N’-(sulfonyldi-4,1-phenylene)bis[2-chloro]-acetamide
  • Correlated keywords
    • NSC30176 PRMT-1 4 CARM-1 SET-7 9 TCE5003 TCE MCF7a Plasmodium anti-malarial Coactivator-Associated
  • Product Overview:
    TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 µM for human PRMT1 in a methylation assay).{38415} It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 µM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 µM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.{38416}

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