TAF 10 Peptide
TAF 10 Peptide
TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.{16903} One vial of this peptide...
€191.00
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€48.00 €40.80
€48.00 €40.80
TC 2559 is a CNS-selective partial agonist for ?4?2 subunit-containing nicotinic acetylcholine receptors (nAChRs) with an EC50 value of 0.18 µM for calcium signaling in HEK293 cells expressing human recombinant nAChRs.{46064,46065} It is selective for ?4?2 over ?2?4, ?4?4, ?3?4, ?3?2, and ?7 subunit-containing nAChRs (EC50s = 14, 12.5, >30, >100, and >100 µM, respectively). It increases dopamine cell firing in the rat ventral tegmental area (VTA) in vitro. TC 2559 increases spontaneous inhibitory postsynaptic currents (sIPSCs) in dorsal horn neurons, indicating an enhancement of inhibitory synaptic transmission, an effect that is blocked by the ?4?2 subunit-containing nAChR antagonist DH?E.{46066} It reduces formalin-induced paw-licking time in mice when administered at doses of 3 and 10 mg/kg and increases paw withdrawal latency in a rat model of chronic constriction injury when administered at a dose of 3 mg/kg. TC 2559 (3 and 6 µmol/kg) also reverses cognitive deficits induced by scopolamine in rats, increasing step-through latency in a passive avoidance task.{46064}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 212332-35-9 |
| Molecular formula | C12H18N2O • 2C4H4O4 |
| Smiles | CNCC/C=C/C1=CC(OCC)=CN=C1.OC(/C=C/C(O)=O)=O.OC(/C=CC(O)=O)=O, CNCC/C=C/C1=CC(OCC)=CN=C1.OC(/C=C/C(O)=O)=O.OC(/C=CC(O)=O)=O, CNCC/C=C/C1=CC(OCC)=CN=C1.OC(/C=C/C(O)=O)=O.OC(/C=CC(O)=O)=O, CNCC/C=C/C1=CC(OCC)=CN=C1.OC(/C=C/C(O)=O)=O.OC(/C=CC(O)=O)=O |
| Molecular weight | 438,4 |
| Custom code | 2933.39 |
| Formulation | A solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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