TB 21007

TB 21007

CAT N°: 27674
Price:

From 165.00 140.25

TB 21007 is an inverse agonist of ?5?3?2 subunit-containing GABAA receptors (Ki = 1.6 nM).{48803} It selectively inhibits ?5?3?2 subunit-containing GABAA receptors over ?1-4 and ?6 subunit-containing GABAA receptors that also contain ?3 and ?2 subunits (Kis = 20, 16, 20, 106, and 1,800 nM, respectively). TB 21007 reduces the latency to find the hidden platform in a matching-to-place variant of the Morris water maze, indicating enhanced spatial memory, in rats when administered at a dose of 0.3 mg/kg. It reduces paw tactile allodynia induced by reserpine (Item No. 16474) in a rat model of fibromyalgia-like pain when administered intrathecally at doses of 1.5, 15, and 150 nmol.{48807}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6,7-dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one
  • Correlated keywords
    • TB21007 ?5 ?3 ? 3 ?2 ? 2 GABA A ? 1 5 6
  • Product Overview:
    TB 21007 is an inverse agonist of ?5?3?2 subunit-containing GABAA receptors (Ki = 1.6 nM).{48803} It selectively inhibits ?5?3?2 subunit-containing GABAA receptors over ?1-4 and ?6 subunit-containing GABAA receptors that also contain ?3 and ?2 subunits (Kis = 20, 16, 20, 106, and 1,800 nM, respectively). TB 21007 reduces the latency to find the hidden platform in a matching-to-place variant of the Morris water maze, indicating enhanced spatial memory, in rats when administered at a dose of 0.3 mg/kg. It reduces paw tactile allodynia induced by reserpine (Item No. 16474) in a rat model of fibromyalgia-like pain when administered intrathecally at doses of 1.5, 15, and 150 nmol.{48807}

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