TAPI-2

TAPI-2

CAT N°: 14695
Price:

From 226.00 192.10

The extracellular domains of many different types of transmembrane proteins, including growth factors, growth factor receptors and cell adhesion molecules, are proteolytically released (shed) in response to environmental cues. TNF protease inhibitor 2 (TAPI-2) is a broad-spectrum inhibitor of TNF-? converting enzyme (TACE), other ADAMs (a disintegrin and metalloproteinases), and other matrix metalloproteinases. It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-?, ? amyloid precursor protein, L-selectin, and IL-6 receptor ? subunit, with an IC50 value of 10 µM.{23493} TAPI-2 inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 µM, respectively.{23492} In T4-2 breast cancer cells, 20 µM TAPI-2 prevented mobilization of the growth factors TGF-? and amphiregulin leading to reversion of the malignant cellular phenotype.{23494}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
  • Correlated keywords
    • proteases inhibitors TACE ADAM MMP TGF TNF cancers APP extracellular signaling growth factors TAPI2 TAPIs 2 two broad spectrum converting enzyme TNF-? TNF-a TNF-alpha TNF-.alpha. TNFa TNFalpha TNF.alpha. TNF? ? a alpha .alpha. disintegrin metalloproteinases matrix proteins amlpod precursor APPs ? APP bAPP betaAPP .beta.APP b-APP beta-APP .beta.-APP ?-APP b beta .beta. ? T4-2 T42 T4 2 four amphiregulin malignant cellular phenotypes phorbol-12-myristate-13-acetate
  • Product Overview:
    The extracellular domains of many different types of transmembrane proteins, including growth factors, growth factor receptors and cell adhesion molecules, are proteolytically released (shed) in response to environmental cues. TNF protease inhibitor 2 (TAPI-2) is a broad-spectrum inhibitor of TNF-? converting enzyme (TACE), other ADAMs (a disintegrin and metalloproteinases), and other matrix metalloproteinases. It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-?, ? amyloid precursor protein, L-selectin, and IL-6 receptor ? subunit, with an IC50 value of 10 µM.{23493} TAPI-2 inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 µM, respectively.{23492} In T4-2 breast cancer cells, 20 µM TAPI-2 prevented mobilization of the growth factors TGF-? and amphiregulin leading to reversion of the malignant cellular phenotype.{23494}

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