Syk Inhibitor

Syk Inhibitor

CAT N°: 14829
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From 48.00 40.80

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcR? chains and mediates downstream signaling related to platelet function and inflammation.{24052} Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits Fc?RI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM).{24050} At 2 ?M, this compound completely abolishes convulxin-induced platelet aggregation and shape change.{24051}

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