Syk Inhibitor

Syk Inhibitor

CAT N°: 14829
Price:

From 48.00 40.80

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcR? chains and mediates downstream signaling related to platelet function and inflammation.{24052} Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits Fc?RI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM).{24050} At 2 ?M, this compound completely abolishes convulxin-induced platelet aggregation and shape change.{24051}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide
  • Correlated keywords
    • OXSI-2 OXSI2 OXSI 2 two inhibitors inhibits inhibitions syk spleens tyrosines kinases immunology ITAM immunoreceptors tyrosine-based based activations motifs FcR? chains Fc receptors inflammation platelets aggregation motifs FcRy FcRgamma FcR.gamma. oxindole functions
  • Product Overview:
    Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcR? chains and mediates downstream signaling related to platelet function and inflammation.{24052} Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits Fc?RI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM).{24050} At 2 ?M, this compound completely abolishes convulxin-induced platelet aggregation and shape change.{24051}

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