Sulindac sulfone

Sulindac sulfone

CAT N°: 16805
Price:

From 48.00 40.80

Sulindac (Item No. 10004386) is a non-steroidal anti-inflammatory drug that has an extensive epidemiology documenting reduced human colorectal cancer. In mouse models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels.{4068} Sulindac sulfone is an oxidized metabolite of sulindac that is produced in many mammals but minimally in mice and rats.{27308,27307} It is generally considered to be inactive against COX enzymes, although it can reduce azoxymethane-induced colon cancer in rats.{12989,27310} Sulindac sulfone inhibits aldose reductase (IC50 = 367 nM) in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications.{27311}

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