Sucrose octasulfate (potassium salt)

Sucrose octasulfate (potassium salt)

CAT N°: 16382
Price:

From 131.00 111.35

Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum?sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.{26734} Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).{26736}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2,3,4,6-tetrakis(hydrogen sulfate),1,3,4,6-tetra-O-sulfo-?-D-fructofuranosyl ?-D-glucopyranoside, octapotassium salt
  • Correlated keywords
    • gastroprotective sucralfate gastrointestinal protectants alkalines inhibitors gastric pH thrombin fibroblasts growths factors FGF-2 antitumors 57680-56-5 Agents M 01 sucrosofate potassiums inhibits inhibitions FGF2 FGF 2 two anti-tumors anti tumors salts K KSOS aluminum-sucrose aluminum complex peptic hydrolysis protects protecting esophageal epithelium acids injury binds exosite II catalytic activity surrogate heparin mouse melanoma lungs carcinoma models preventing prevents 2 two FGF2 FGF binding endothelial cells removing removes pre-bound prebound
  • Product Overview:
    Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum?sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.{26734} Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).{26736}

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