Suberohydroxamic Acid

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • N1,N8-dihydroxy-octanediamide
• Correlated keywords
  • histones deacetylases HDACs inhibitors genes expression regulation epigenetics nucleosomes HDAC1 HDAC3 differentiation cells cycle arrest apoptosis cancers suberodihydroxamic acid suberoyl bishydroxamic acid inhibited inhibition Warner-Lambert Brand of Mefenamic Acid Warner Lambert Brand of Mefenamic Acid Pharmascience Brand of Mefenamic Acid First Horizon Brand of Mefenamic Acid Parke Davis Brand of Mefenamic Acid Farmasierra Brand of Mefenamic Acid Ashbourne Brand of Mefenamic Acid Pinewood Brand of Mefenamic Acid Nu-Pharm Brand of Mefenamic Acid Nu Pharm Brand of Mefenamic Acid Chemidex Brand of Mefenamic Acid Gödecke Brand of Mefenamic Acid Clonmel Brand of Mefenamic Acid Antigen Brand of Mefenamic Acid Pfizer Brand of Mefenamic Acid Apotex Brand of Mefenamic Acid Rowa Brand of Mefenamic Acid Elan Brand of Mefenamic Acid APS Brand of Mefenamic Acid PMS-Mefenamic Acid PMS Mefenamic Acid Acid Mefenaminic Mefenaminic Acid Acid Mefenamic Mefenamic Acid Forte Ponstan Ponstan Forte Apo-Mefenamic Apo Mefenamic Nu-Mefenamic Nu Mefenamic ApoMefenamic NuMefenamic Pinalgesic Contraflam Ponalgic Parkemed Ponstel Ponstan Ponalar Mefacit Pontal Ponsyl Ponmel Dysman Coslan Mefic Mefac
• Product Overview:
  Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 ?M) and HDAC3 (IC50 = 0.30 ?M).{17174} SBHA causes cell differentiation, cell cycle arrest, or apoptosis.{18561,18558,18559,18557,18556} HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.{18560,18446}