SU 5614

SU 5614

CAT N°: 17410
Price:

From 48.00 40.80

SU 5614 is a chlorinated derivative of SU 5416 (Item No. 13342) and a multi-kinase inhibitor.{37298} It inhibits growth and induces apoptosis in Ba/F3 and acute myeloid leukemia (AML) cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 ?M). SU 5614 also inhibits C-KIT, VEGFR, and PDGFR? in vitro (IC50s = 0.03, 0.46, and 0.36 ?M, respectively).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3Z)-5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
  • Correlated keywords
    • 186611-56-3 1097886-11-7 SU5614 NIHPTC A-375 SU5416 PTC-2 BaF3 TPC1 vascular endothelial growth factor fibroblast
  • Product Overview:
    SU 5614 is a chlorinated derivative of SU 5416 (Item No. 13342) and a multi-kinase inhibitor.{37298} It inhibits growth and induces apoptosis in Ba/F3 and acute myeloid leukemia (AML) cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 ?M). SU 5614 also inhibits C-KIT, VEGFR, and PDGFR? in vitro (IC50s = 0.03, 0.46, and 0.36 ?M, respectively).

We also advise you