Stiripentol

Stiripentol

CAT N°: 17781
Price:

From 102.00 86.70

Stiripentol is a third-generation antiepileptic compound.{28852} It is a positive allosteric modulator of GABAA receptors, potentiating GABA-mediated activation to a greater extent in receptors expressing ?3 subunits and to a lower extent in those containing ?1 or ? subunits.{48495} It also inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices.{28852,48496} Stiripentol (500 µM) inhibits lactate dehydrogenase (LDH), blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH1 and LDH5.{28811} Formulations containing stiripentol have been used in the adjunctive treatment of seizures associated with Dravet syndrome.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol
  • Correlated keywords
    • 131206-47-8 anti-epileptic GABA A ? 3 ? 1 LDH 5 BCX2600 Diacomit
  • Product Overview:
    Stiripentol is a third-generation antiepileptic compound.{28852} It is a positive allosteric modulator of GABAA receptors, potentiating GABA-mediated activation to a greater extent in receptors expressing ?3 subunits and to a lower extent in those containing ?1 or ? subunits.{48495} It also inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices.{28852,48496} Stiripentol (500 µM) inhibits lactate dehydrogenase (LDH), blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH1 and LDH5.{28811} Formulations containing stiripentol have been used in the adjunctive treatment of seizures associated with Dravet syndrome.

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