STING R224 variant (human, recombinant)

STING R224 variant (human, recombinant)

CAT N°: 23593
Price:

890.00 756.50

STING R224 variant (human, recombinant) contains amino acids 138-379 of the wild-type variant (R232) with lysine 224 substituted with arginine. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-?B and transcription of immunomodulatory genes, including type I interferon (IFN).{22400,22401,24611,24607} The R232 variant of STING is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} The SNP variant H232 is found at a 13.7% frequency. The K224R mutation prevents ubiquitination of STING at position K224, a process which is essential for efficient cytosolic DNA-mediated signaling.{34537} Therefore, this mutation disrupts optimal STING trafficking, which inhibits TBK1-mediated IRF3 activation but not NF-?B activation.

Territorial Availability: Available through Bertin Technologies only in France

  • Correlated keywords
    • TMEM-173 MITA Methionine-Proline-Tyrosine-Serine plasma membrane tetraspanner IRF-3 NET-23 R-232 NFkB H-232 TBK-1 escherichia eris hsting mp?s net23 savi transmembrane protein 173 K-224R Q86WV6 mutant
  • Product Overview:
    STING R224 variant (human, recombinant) contains amino acids 138-379 of the wild-type variant (R232) with lysine 224 substituted with arginine. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-?B and transcription of immunomodulatory genes, including type I interferon (IFN).{22400,22401,24611,24607} The R232 variant of STING is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} The SNP variant H232 is found at a 13.7% frequency. The K224R mutation prevents ubiquitination of STING at position K224, a process which is essential for efficient cytosolic DNA-mediated signaling.{34537} Therefore, this mutation disrupts optimal STING trafficking, which inhibits TBK1-mediated IRF3 activation but not NF-?B activation.

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