Sterculic Acid

Sterculic Acid

CAT N°: 26735
Price:

598.00 508.30

Sterculic acid is a cyclopropene fatty acid that has been found in S. foetida.{46110} It is an inhibitor of ?9-desaturase that decreases 9(Z)-myristoleic acid (Item No. 9002461) and increases oleic acid (Item No. 90260) and 9(Z),11(E)-conjugated linoleic acid (Item No. 90140) levels in the milk of lactating ewes when administered at a dose of 0.5 g per day.{48112} It also inhibits endoplasmic reticulum stress induced by 7-keto cholesterol (Item No. 16339) in ARPE-19 cells when used at a concentration of 1 µM and prevents the formation of choroidal neovascularization when applied to eyes at concentrations of 0.1 to 10 mM in a rat model of macular degeneration induced by laser injury.{46110} Sterculic acid binds to a variety of kinases, including calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2), mammalian sterile20-related kinase 3 (MST3), and p90 ribosomal S5 kinase 4 (RSK4).{46111} [Matreya, LLC. Catalog No. 1235]

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-octyl-1-cyclopropene-1-octanoic acid
  • Correlated keywords
    • FA Sterculia ARPE19 CAMKK MST RSK S-5 p-90 ketocholesterol stearculic stearculinic sterculinic sterile 20
  • Product Overview:
    Sterculic acid is a cyclopropene fatty acid that has been found in S. foetida.{46110} It is an inhibitor of ?9-desaturase that decreases 9(Z)-myristoleic acid (Item No. 9002461) and increases oleic acid (Item No. 90260) and 9(Z),11(E)-conjugated linoleic acid (Item No. 90140) levels in the milk of lactating ewes when administered at a dose of 0.5 g per day.{48112} It also inhibits endoplasmic reticulum stress induced by 7-keto cholesterol (Item No. 16339) in ARPE-19 cells when used at a concentration of 1 µM and prevents the formation of choroidal neovascularization when applied to eyes at concentrations of 0.1 to 10 mM in a rat model of macular degeneration induced by laser injury.{46110} Sterculic acid binds to a variety of kinases, including calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2), mammalian sterile20-related kinase 3 (MST3), and p90 ribosomal S5 kinase 4 (RSK4).{46111} [Matreya, LLC. Catalog No. 1235]

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