Staurosporine

Staurosporine

CAT N°: 81590
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From 48.00 40.80

Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM.{9054} It inhibits rat recombinant PKC-? approximately 100- and 1,000-fold better than PKC-? and PKC-?, respectively.{9107} However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms.{9106} The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.{9106,8207}

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