Stattic

Stattic

CAT N°: 14590
Price:

From €85.00 €72.25

Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities.{23053} Stattic is a small molecule inhibitor of STAT3.{23053} It selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC50 = 5.1 ?M at 37°C).{23053} At 10 ?M, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.{23053}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-nitro-1,1-dioxide-benzo[b]thiophene
  • Correlated keywords
    • signals transducers activators transcriptions factors STAT3 tumors cancers inhibitors inhibits inhibitions STAT-3 3 three inhibitory compounds small molecules activation activates active dimerization nuclear translocation prevents preventing binding binds binders tyrosine-phosphorylated peptides motifs SH2 SH-2 SHs 2 domains breasts MDA-MB-231 MDA-Mb-435S cells lines latent cytoplasmic signaling membranes nucleus humans aberrant upstream apoptosis induces STAT three inhibitory compounds MB4355 MB 4355
  • Product Overview:
    Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities.{23053} Stattic is a small molecule inhibitor of STAT3.{23053} It selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC50 = 5.1 ?M at 37°C).{23053} At 10 ?M, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.{23053}

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