SR9011

SR9011

CAT N°: 11930
Price:

From 140.00 119.00

SR9011 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERB? and REV-ERB? with IC50 values of 790 and 560 nM, respectively.{21074} It has no activity at other nuclear receptors. SR9011 blocks the activity of the suprachiasmatic nucleus (SCN) clock, with reversible inhibition of circadian oscillation in SCN explants cultured from Per2-luc reporter mice.{21074} The circadian pattern of expression of several metabolic genes in liver, skeletal muscle, and adipose tissue was also shown to be altered in mice exposed to SR9011, resulting in increased energy expenditure.{21074}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide
  • Correlated keywords
    • SR-9011 REV-ERB? REV-ERB? REV-ERBa REV-ERBb REV-ERB? REV-ERB suprachiasmatic nucleus SCN circadian oscillation Per2-luc
  • Product Overview:
    SR9011 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERB? and REV-ERB? with IC50 values of 790 and 560 nM, respectively.{21074} It has no activity at other nuclear receptors. SR9011 blocks the activity of the suprachiasmatic nucleus (SCN) clock, with reversible inhibition of circadian oscillation in SCN explants cultured from Per2-luc reporter mice.{21074} The circadian pattern of expression of several metabolic genes in liver, skeletal muscle, and adipose tissue was also shown to be altered in mice exposed to SR9011, resulting in increased energy expenditure.{21074}

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