Splitomicin

Splitomicin

CAT N°: 13168
Price:

From 48.00 40.80

Sir2p, the product of the SIR2 gene, is a conserved NAD+-dependent histone deacetylase (HDAC) involved in the regulation of the lifespan in yeast. It plays roles in silencing gene expression and negatively regulates the initiation of DNA replication. Splitomicin is a small molecule inhibitor of Sir2p histone deacetylase activity, displaying higher activity in vivo (minimal inhibitory concentration = 0.49 µM) than in vitro (IC50 = 60 µM).{18318,18319,18320} It less effectively inhibits yeast Hst1, a paralog of Sir2p.{18319} Splitomicin has diverse effects on mammalian cells.{18321,18322,18323}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1,2-dihydro-3H-naphtho[2,1-b]pyran-3-one
  • Correlated keywords
    • sirtuins Sir2p Sir-2p Sir 2p SIR2 NAD NAD+-dependent NAD-dependent dependent histone deacetylase activity activities genes regulations lifespan life-span life span yeast expression DNA replication inhibitor inhibits inhibition Hst1 Hst-1 Hst 1 HDACs chromatin research epigenetics regulation modification Sirs small molecules Pyrones
  • Product Overview:
    Sir2p, the product of the SIR2 gene, is a conserved NAD+-dependent histone deacetylase (HDAC) involved in the regulation of the lifespan in yeast. It plays roles in silencing gene expression and negatively regulates the initiation of DNA replication. Splitomicin is a small molecule inhibitor of Sir2p histone deacetylase activity, displaying higher activity in vivo (minimal inhibitory concentration = 0.49 µM) than in vitro (IC50 = 60 µM).{18318,18319,18320} It less effectively inhibits yeast Hst1, a paralog of Sir2p.{18319} Splitomicin has diverse effects on mammalian cells.{18321,18322,18323}

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