Specnuez<wbr/>henide

Specnuezhenide

CAT N°: 26385
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From 122.00 103.70

Specneuzhenide is an iridoid glycoside originally isolated from L. lucidum with diverse biological activities.{45121,45122,45123,45124} It reduces neurotoxicity induced by 6-OHDA (Item No. 25330) in SH-SY5Y cells by 49.2% when used at a concentration of 10 ?M.{45121} Specneuzhenide (25, 50, and 100 ?M) reduces high glucose-induced levels of cleaved caspase-3 protein and apoptosis in mouse glomerular mesangial cells.{45122} It increases cell viability and alkaline phosphatase activity in osteoblastic UMR-106 cells.{45123} Specneuzhenide inhibits hypoxia-induced VEGFA secretion, VEGFA and prolyl hydroxylase 2 (PHD-2) mRNA expression, and protein levels of VEGFA, HIF-1?, and PHD-2 in human acute retinal pigment epithelial-19 (ARPE-19) cells.{45124} In vivo, specneuzhenide (5 and 10 mg/kg) prevents retinal neovascularization in a rat model of oxygen-induced retinopathy.

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