Sp-<wbr/>Cyclic AMPS (sodium salt)

Sp-Cyclic AMPS (sodium salt)

CAT N°: 14983
Price:

From 102.00 86.70

Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases.{24263} Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF domain (EC50 = 40 ?M).{24263} It has been used to study GAF-mediated stimulation of PDE10.{24263}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • cyclic 3′,5′-[hydrogen (S)-phosphorothioate] adenosine, monosodium salt
  • Correlated keywords
    • 71774-13-5 cAMPs analogs phosphodiesterases PDE10 PDEs PDE-10 10 ten GAF domains cGMP adenylyl cyclases guanylyl cGMP-specific stimulated phophodiesterases Anabaena Escherichia coli FhIA nucleototides derivatives SpcAMPS Sp cAMPS binds binding binders stimulations cAMPS phosphatases intracellular signals transductions
  • Product Overview:
    Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases.{24263} Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF domain (EC50 = 40 ?M).{24263} It has been used to study GAF-mediated stimulation of PDE10.{24263}

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