Sp-<wbr/>Cyclic AMPS (sodium salt)

Sp-Cyclic AMPS (sodium salt)

CAT N°: 14983
Price:

From 102.00 86.70

Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases.{24263} Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF domain (EC50 = 40 ?M).{24263} It has been used to study GAF-mediated stimulation of PDE10.{24263}

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