€268.00 €227.80
Somatotropin is a circulating peptide hormone encoded by GH1 in humans that has roles in growth, cellular proliferation and differentiation, muscle and bone anabolism, and lipolysis.{52624} Alternative splicing of the GH1 pre-mRNA produces one full-length 22 kDa isoform and a short-length 20 kDa isoform, which has reduced affinity for the somatotropin receptor.{52625} Somatotropin contains a central hydrophobic core and a bundle of four ?-helices that forms two somatotropin receptor binding sites.{52626} It is synthesized and stored by somatotrophs in the anterior pituitary gland and is secreted episodically as a monomer or dimer in a circadian rhythm that peaks during night sleep.{52626,52625} Somatotropin production is induced by stimulation with growth hormone-releasing hormone, ghrelin, or sex steroids and inhibited by somatostatin, IGF-1, or glucocorticoid stimulation.{52627} Binding of somatotropin to the somatotropin receptor, which is ubiquitously expressed, activates a variety of intracellular signal transduction pathways, including JAK-STAT, that lead to IGF-1, MAPK, PPAR? (Item No. 61700), or SIRP? signaling.{52628,52624,52626} Decreased serum levels of somatotropin have been found in patients with dwarfism.{52629} Increased somatotropin serum levels have been found in patients with acromegaly, a condition characterized by abnormal bone growth, and are positively correlated with early mortality.{52629,52630} Cayman’s Somatotropin Long Isoform (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 212 amino acids and has a calculated molecular weight of 24.7 kDa.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 50 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | Lyophilized from sterile PBS, pH 7.4 |
| Purity | ≥85% as determined by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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