€1,237.00 €1,051.45
SNX-482 is a peptide originally isolated from H. gigas venom that acts as a class E/R-type voltage-sensitive calcium channel blocker (IC50 = 30 nM in 192C cells expressing human class E channels).{57113} It is selective for class E/R-type over class A and class B calcium channels (IC50s = >280 and ~800 nM, respectively), as well as the voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.4 (IC50s = >140 nM for all). SNX-482 inhibits class E/R-type calcium currents in isolated rat posterior pituitary (IC50 = 4 nM), however, it has no effect on class E/R-type calcium currents in isolated rat granule cells, retinal ganglion cells, or hippocampal pyramidal cells at concentrations up to 200 nM. Intrathecal administration of SNX-482 (0.5 µg/animal) inhibits formalin-induced neurokinin-1 (NK1) receptor internalization and cfos expression in the ipsilateral dorsal horn and reduces formalin-induced paw flinching in rats.{57114}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 203460-30-4 |
| Molecular formula | C192H274N52O60S7 |
| Smiles | O=C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N[C@@H](CSSC[C@H](N1)C(N2CCC[C@H]2C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC3=O)=O)CC(C)C)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CCSC)C(N[C@H](C(NCC(NCC(N[C@@H](CSSC[C@H](N3)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC6=CC=C(O)C=C6)C7=O)=O)=O)CC8=CC=CC=C8)=O)CC(C)C)=O)=O)=O)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@H](N7)C(N[C@H](C(N[C@@H](CC9=CNC=C9C=CC=C)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)CC=CC=CC=C)=O)=O)CC(C)C)=O)=O)=O)C)=O)C1=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC=CC=CC=C)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)CN[H] |
| Molecular weight | 4495 |
| Formulation | A solid |
| Purity | ≥98% |
| Custom code | 2924.29 |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
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