SMU127

SMU127

CAT N°: 33147
Price:

From 122.00 103.70

SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.{60511} It induces NF-?B signaling in cells expressing human TLR2 (EC50 = 0.55 µM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 µM. SMU127 induces the production of TNF-? in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 µM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5,6-dihydro-2-[[(4-methyl-1-piperazinyl)carbonyl]amino]-4H-cyclopenta[b]thiophene-3-carboxylic acid, ethyl ester
  • Correlated keywords
    • ZINC-666243 SMU-127 TLR-1 NF?B TLR4 TLR5 TLR7 TLR8 TNF?
  • Product Overview:
    SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.{60511} It induces NF-?B signaling in cells expressing human TLR2 (EC50 = 0.55 µM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 µM. SMU127 induces the production of TNF-? in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 µM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.

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