SMER28

SMER28

CAT N°: 17768
Price:

From 74.00 62.90

SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington’s, Parkinson’s, and Alzheimer’s diseases.{31378,31377,31379} SMER28 induces clearance of amyloid-? (A?) peptides and the amyloid precursor protein c-terminal fragment (APP-CTF) in mouse embryonic fibroblasts (MEFs) isolated from wild-type, but not autophagy-related protein 5 knockout (Atg5-/-), mouse embryos in a concentration-dependent manner.{41265} It induces autophagy independently of rapamycin (Item No. 13346) in mammalian cells at a concentration of 47 µM.{31378} SMER28 also promotes reprogramming of fibroblasts into neural stem cells when used in combination with other chemical reagents.{31158}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-bromo-N-2-propen-1-yl-4-quinazolinamine
  • Correlated keywords
    • SMER-28 6-bromo-4-allylaminoquinazoline
  • Product Overview:
    SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington’s, Parkinson’s, and Alzheimer’s diseases.{31378,31377,31379} SMER28 induces clearance of amyloid-? (A?) peptides and the amyloid precursor protein c-terminal fragment (APP-CTF) in mouse embryonic fibroblasts (MEFs) isolated from wild-type, but not autophagy-related protein 5 knockout (Atg5-/-), mouse embryos in a concentration-dependent manner.{41265} It induces autophagy independently of rapamycin (Item No. 13346) in mammalian cells at a concentration of 47 µM.{31378} SMER28 also promotes reprogramming of fibroblasts into neural stem cells when used in combination with other chemical reagents.{31158}

We also advise you