Sevoflurane

Sevoflurane

CAT N°: 23996
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102.00 86.70

Sevoflurane is a halogenated ether with anesthetic properties.{41455} It enhances the activity of GABAA and glycine receptors and inhibits the activity of nicotinic acetylcholine receptors (nAChRs) and glutamate receptors. Sevoflurane enhances the responses of ?2?1 subunit-containing GABAA and ?1 subunit-containing glycine receptors at submaximal agonist concentrations in HEK293 cells (EC50s = 0.45 and 0.36 mM, respectively).{41456} Sevoflurane (360 µM) also increases the amplitude of GABAA receptor responses to GABA stimulation for receptors with an ?1?2?2 subunit composition.{41457} It inhibits binding of the high affinity nicotinic agonist epibatidine to nAChRs in mouse brain membranes (IC50 = 0.77 mM).{41458} Formulations containing sevoflurane have been used in the induction and maintenance of general anesthesia.

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